Rabies superantigen as a Vbeta T-dependent adjuvant.
نویسندگان
چکیده
منابع مشابه
Rabies superantigen as a Vbeta T-dependent adjuvant
Recently we reported evidence that nucleocapsid (NC) of rabies virus is a Vbeta8-specific exogenous superantigen (SAg) in humans and a Vbeta6-specific SAg in BALB/c mice. NC was also found to stimulate rabies vaccination by enhancing the rabies neutralizing antibody response. In this study, we tested the hypothesis that the stimulating effect of NC and its SAg properties are linked. To do this,...
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The nucleocapsid (NC) of the rabies virus behaves as an exogenous superantigen (SAg) in humans. In the present report, we analyzed whether it is also a SAg in mice by studying the effect of NC on T cell receptor (TCR) V beta expression in BALB/c mice. Repeated injection of NC in newborn BALB/c mice led to a marked reduction by two- to sixfold of V beta 6 expressing CD4+ T cells in spleen and in...
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PURPOSE Myeloid differentiation factor 88 (Myd88), a ubiquitous Toll-like receptor adaptor molecule, has been reported to play important roles in B cell responses to infections and vaccination. The present study evaluated the effects of genetic adjuvanting with Myd88 on the immune responses to a plasmid DNA rabies vaccine. MATERIALS AND METHODS Plasmids encoding rabies glycoprotein alone (pIR...
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From the * Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York 10029; the ‡ Howard Hughes Medical Institute, The Rockefeller University, New York 10021; the § Howard Hughes Medical Institute, Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York 10029; and the i Immunology Program, Graduate School of Medical Sciences, and the Department of Medicine, Cornell Universit...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1996
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.183.4.1623